REVLEX® should be applied topically on the affected area 2-4 times daily to maximize relief. It is important not to only apply REVLEX® to the painful area only. Muscle pain is often a referred pain and may not be where the pain is originating from. That is why it is important to apply treatment on areas that you may not feel pain. Please click here to see the REVLEX® Muscle Relief applications zones. The application zones map is included in each box of REVLEX® Muscle Pain Relief.